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    • Excitement as trial shows Huntington´s drug could slow progress of disease

      Hailed as ?enormously significant?, results in groundbreaking trial are first time a drug has been shown to suppress effects of Huntington?s genetic mutation

      A landmark trial for Huntington?s disease has announced positive results, suggesting that an experimental drug could become the first to slow the progression of the devastating genetic illness.

      The results have been hailed as ?enormously significant? because it is the first time any drug has been shown to suppress the effects of the Huntington?s mutation that causes irreversible damage to the brain. Current treatments only help with symptoms, rather than slowing the disease?s progression.

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    • David Davis retracts suggestion UK could back out of Brexit deal on Irish border - Politics live

      Rolling coverage of the day?s political development as they happen, including Theresa May?s statement to MPs about the UK-EU Brexit deal

      John McDonnell, the shadow chancellor, has been outlining Labour?s policy on the single market and customs union at an event in London, and it?s fair to say there?s still some constructive ambiguity going on.

      Asked whether his opposition to the UK remaining in the single market after Brexit was tougher than Keir Starmer?s view, the shadow chancellor said he and the shadow Brexit secretary were in full agreement. He said:

      What I said was, remaining in the single market would not respect the referendum result. But we?ve been using the phraseology ?a single market?, not ?the single market? and ?a customs union? and not ?the customs union?. Therefore a reformed single market or a new negotiated relationship with the single market. And Keir was exactly putting our position yesterday. We want to be as close as we possibly can to ensure a tariff-free access.

      It isn?t just about semantics, it?s about achieving the objectives that we want overall, which is protecting the economy and protecting jobs.

      Lucy Fisher, one of the Times?s reporters who wrote the Times splash that David Davis was so rude about (see 10.01am), says that Davis?s claim about being misreported is ?disingenuous?.

      David Davis clutching at straws!

      Yday said gvt´s Brexit compromise on Ireland was "statement of intent... much more than legally enforceable". Cue big row with Ireland.

      Today insists on @LBC he genuinely meant *innocent face* it is more than legally enforceable. Disingenuous.

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    • Snow and ice disrupts travel across UK as hundreds of schools close ? live

      Plunging temperatures, ice and snow forecast to combine to create treacherous conditions on the roads and railways

      If you have to drive in the snow and ice, here?s a guide to staying safe:

      Stay safe and plan ahead

      The daytime temperature yesterday was the coldest in seven years, the BBC says.

      Yesterday was the coldest day we´ve had since December 2010. Braemar saw a max day temp of -6.2C. Brrrrrr! Jo

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    • Grenfell Tower: police investigating corporate manslaughter offences

      Public inquiry into London fire hears Met officers considering multiple offences including misconduct in public office

      Criminal offences of manslaughter, corporate manslaughter, misconduct in public office and breaches of fire safety legislation are being considered by the police investigation into the Grenfell Tower fire.

      Updating the public inquiry on the progress of the parallel police inquiry, Jeremy Johnson QC, for the Metropolitan police, told a hearing in London that 31m documents had been obtained.

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    • Brexit: City of London will lose 10,500 jobs on day one, says EY

      Dublin and Frankfurt are most likely to benefit from UK?s departure from EU, says accountancy firm

      City firms plan to move 10,500 jobs out of the UK on ?day one? of Brexit, with Dublin and Frankfurt the financial centres most likely to benefit from the UK?s departure from the EU.

      The job tracker compiled by accountants EY, which counts job announcements to the end of November, found that the number of roles likely to be affected had fallen from estimates of 12,500 a year ago. But it also concluded that the jobs being affected by Brexit were not just the ?back office? ones initially forecast, but ?front office? staff who deal directly with clients.

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